A new urease inhibitor from Viola betonicifolia.

نویسندگان

  • Naveed Muhammad
  • Muhammad Saeed
  • Ajmal Khan
  • Achyut Adhikari
  • Abdul Wadood
  • Khalid Mohammed Khan
  • Vincenzo De Feo
چکیده

Urease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. Moreover, urease is the major cause of pathologies induced by H. pylori, such as gastritis and peptic ulcer. In the present work, the new natural compound, 3-methoxydalbergione, was isolated from Viola betonicifolia. A mechanistic study of this compound as a natural urease inhibitor was performed by using enzyme kinetics and docking studies. 3-Methoxydalbergione could be considered as a lead molecule for drugs useful in the urease associated diseases.

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Author's response to reviews Title: Prokinetic and laxative effects of the crude methanolic extract of Viola betonicifolia whole plant in rodents Authors:

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عنوان ژورنال:
  • Molecules

دوره 19 10  شماره 

صفحات  -

تاریخ انتشار 2014