A new urease inhibitor from Viola betonicifolia.
نویسندگان
چکیده
Urease has attracted much attention, as it is directly involved in the formation of infection stones and contributes to the pathogenesis of urolithiasis, pyelonephritis, ammonia and hepatic encephalopathy, hepatic coma and urinary catheter encrustation. Moreover, urease is the major cause of pathologies induced by H. pylori, such as gastritis and peptic ulcer. In the present work, the new natural compound, 3-methoxydalbergione, was isolated from Viola betonicifolia. A mechanistic study of this compound as a natural urease inhibitor was performed by using enzyme kinetics and docking studies. 3-Methoxydalbergione could be considered as a lead molecule for drugs useful in the urease associated diseases.
منابع مشابه
Author's response to reviews Title: Prokinetic and laxative effects of the crude methanolic extract of Viola betonicifolia whole plant in rodents Authors:
Title: Prokinetic and laxative effects of the crude methanolic extract of Viola betonicifolia whole plant in rodents
متن کاملProkinetic and laxative effects of the crude methanolic extract of Viola betonicifolia whole plant in rodents
BACKGROUND The present study was aimed to provide ethnopharmacological basis for the medicinal use of Viola betonicifolia whole plant in indigestion and constipation. METHODS Mice were used in in-vivo prokinetic and laxative studies while in-vitro experiments were conducted on isolated tissues of rabbit and guinea-pig gut preparations suspended in a tissue bath to measure isotonic contraction...
متن کاملEvaluation of Viola betonicifolia for its nutrition value.
In the present study, Viola betonicifolia (whole plant) and solvent fractions obtained thereof were evaluated for various micronutrients such as lead, copper, chromium, iron, nickel, zinc, cadmium, cobalt and macronutrients such as sodium, potassium and calcium using atomic absorption spectrophotometer and flame photometry respectively. It was observed that cobalt and cadmium were not detectibl...
متن کاملAnalgesic and Anti-inflammatory Profile of n-Hexane Fraction of Viola betonicifolia
Purpose: To evaluate the analgesic and anti-inflammatory activities of n-hexane extract of the whole plant of Viola betonicifolia Sm, family: Violaceace. Methods: The n-hexane fraction of Viola betonicifolia (VBHF) was tested for its analgesic and antiinflammatory activities (carrageenan-induced and histamine-induced edema models) in BALB/c mice. Results: VBHF exhibited significant (p < 0.01) a...
متن کاملSynthesis of Some Spiro Indeno[1,2-b]pyrido[2,3-d]Pyrimidine-5,3′- Indolines as New Urease Inhibitors
New series of spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3′-indolines as new urease inhibitors were synthesized by the catalytic procedure in high yield and short reaction time. In this method, biacidic carbon was prepared as a novel heterogeneous acid and was subsequently used as an efficient catalyst in this synthesis. The inhibitory activities of synthesized compounds were tested against Ja...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Molecules
دوره 19 10 شماره
صفحات -
تاریخ انتشار 2014